Roxithromycin side chain

May 1, 2000 The semisynthetic antibiotic roxithromycin (RXM) exists in an of the cladinose moiety and 5) dealkylation of the oxime ether side chain AIM To investigate the metabolism of roxithromycin. tRXMi in rat liver thylation and oxime ether side chain O-dealkylation are main biotransi39orrnation

Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring

Sep 12, 2006 Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the Identification of the metabolites of roxithromycin in humans. Zhong D 4) hydrolysis of the cladinose moiety and 5) dealkylation of the oxime ether side chain

Identification of the Metabolites of Roxithromycin in Humans

This result suggests that HMR 3004 (the strongest inhibitory drug, likely owing to its quinoline side chain) and roxithromycin act on a cellular target upstream of Methods: The degradation kinetics and products of roxithromycin were investigated in simulated Although the presence of the oxime ether side chain at the 9-

method for the determination of roxithromycin in bulk and pharmaceutical However, an N-oxime side chain is attached to the lactone ring. It is also currently Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring